The The Effect of Anastatica hierochuntica (Fatimah Grass) on Oxytocin Levels and Uterine Contractions: an Experimental Study
Main Article Content
Abstract
Background: One of the global targets of the Sustainable Development Goals (SDGs) in 2030 is to reduce maternal mortality rate (MMR) to below 70/100.000 live births and infant mortality rate (IMR) to 2/1000 live births. One of the factors that complicates childbirth is inadequate contractions, which is influenced by oxytocin. Oxytocin is a hormone secreted by neurohypophysis that causes uterine contractions during delivery. One of the traditional herbs that can be used to increase contractions is Fatimah grass (Anastatica hierochuntica). A. hierochuntica was used in Arabs, Indonesia, and Malaysia (63,9%) to shorten labor time, breastfeeding, and reduce postpartum hemorrhage by traditional.
Purpose: This purpose was to identify the potency of A. hierochuntica as an oxytocin stimulator by invitro and invivo study.
Methods: The method used a true experiment with a double-blind randomized controlled trial (RCT) and posttest design with a control group design of four groups (G1-G4). The research subject was 28 pregnant mice.
Results: The results of this research were A. hierochuntica has flavonoids, terpenoids, steroids, alkaloids, phenolic, tannin, and saponin secondary metabolites. A. hireochuntica have activity to increase the oxytocin hormone levels in pregnant mice (G1 averaged 49.79; G2 averaged 83.38; G3 averaged 91.05; and G4 averaged 101.39 pg/ml), increase the contraction of onset time (G2 averaged 17; G2 averaged 14.71; and G4 averaged 13.57 minutes) and shorten labor time.
Conclusion: The use of A. hierochuntica decoction significantly increases levels of the oxytocin and uterine contractions. The use of A. hireochuntica in delivery women as traditional herbs requires monitoring from health workers because of its strong ability to increase contractions, and must be done carefully with health worker recommendation.
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
Articles and files in this journal are licensed under a Creative Commons Attribution 4.0 International License.
References
REFERENCES
Abate, A., & Amanuel, A. (2012). Joint Review Mission: Final Report.
Abdulfattah, S. Y. (2013). Study of Immunological Effect of Anastatica Hierochuntica (Kaff Maryam) Plant Methanolic Extract on Albino Male Mice. Journal of Biotechnology Research Center, 7(1), 3–10.
Acevedo-Rodriguez, A., Mani, S. K., & Handa, R. J. (2015). Oxytocin and estrogen receptor ? in the brain: An overview. In Frontiers in Endocrinology (Vol. 6, Issue OCT). https://doi.org/10.3389/fendo.2015.00160
Aguilar, H. N., & Mitchell, B. F. (2010). Physiological Pathways And Molecular Mechanisms Regulating Uterine Contractility. Human Reproduction Update, 16(6), 725–744. https://doi.org/10.1093/humupd/dmq016
Al-Khafaji, A. N. (2018). Therapeutically and Synergism Effect Between Anastatica Hierochuntica and Antibiotics Against Multidrug Resistance Bacteria Isolate from Endometritis. Biochemical and Cellular Archives Journal, 18(2), 2143–2150.
Al-sultany, A. kariem, Al-Rahimy, S. K., Shaheed, K. abdulAlee, & Khalaf, M. A. (2019). Study of The Effect of Anastatica Hierochuntica L. Extracts in Aspects of The Life Performance of Tribolium Castaneum with The Diagnosis of Active compounds using GC-MAS. Biomedical Research, 30(1), 1–8. https://doi.org/10.35841/biomedicalresearch.30-18-1181
Alatshan, A., Qnais, E., Wedyan, M., Bseiso, Y., Alzyoud, E., Banat, R., & Alkhateeb, H. (2018). Antinociceptive and Antiinflammatory Activities of Anastatica hierochuntica and Possible Mechanism of Action. Indian Journal of Sciences, 80(May), 637–646.
Algamdi, N., Mullen, W., & Crozier, A. (2011a). Tea prepared from Anastatica hirerochuntica seeds contains a diversity of antioxidant flavonoids, chlorogenic acids and phenolic compounds. Phytochemistry, 72(2–3), 248–254. https://doi.org/10.1016/j.phytochem.2010.11.017
Algamdi, N., Mullen, W., & Crozier, A. (2011b). Tea Prepared from Anastatica Hirerochuntica Seeds Contains a Diversity of Antioxidant Flavonoids, Chlorogenic Acids and Phenolic Compounds. Phytochemistry Journal, 72(2–3), 248–254. https://doi.org/10.1016/j.phytochem.2010.11.017
Ali, B. H., Baker, R. K., Mohammd, T. U., & Hassn, H. A. (2013). Anastatica Hierochuntica L. Used As an Alternative of Conjugated Estrogen (Premarin) in Rabbit Females. Journal of Advances in Chemistry, 9(1), 1783–1786. https://doi.org/10.24297/jac.v9i1.2302
Astutik, H., Santoso, B., & Agil, M. (2020). The Effect of Anastatica Hierochuntica L. Extract on the Histology of Myometrial Cells and Prostaglandin Levels (PGE2, PGF2?) in Pregnant Mice. 22(Ishr 2019), 81–86. https://doi.org/10.2991/ahsr.k.200215.016
Baldisserotto, Filha, T., & Gama, D. (2016). Good Practices According to WHO’s Recommendation for Normal Labor and Birth and Women’s Assessment of the Care Received: The “Birth in Brazil” National Research study, 2011/2012. Reproductive Health, 13(3). https://doi.org/10.1186/s12978-016-0233-x
Benyagoub, E., Razni, D., & Moghtet, S. (2017). Phytochemical Composition of Anastatica Hierochuntica L., Can It Fight The Toxigenic Bacterial Agents Responsible for Food Poisoning? Microbes and Health Journal, 6(1), 5–8. https://doi.org/10.3329/mh.v6i1.34063
Çalik, K. Y., Karabulutlu, Ö., & Yavuz, C. (2018). First do no harm - Interventions during labor and maternal satisfaction: A descriptive cross-sectional study. BMC Pregnancy and Childbirth, 18(1), 1–10. https://doi.org/10.1186/s12884-018-2054-0
Calixto, J. B. (2000). Efficacy, Safety, Quality Control, Marketing and Regulatory Guidelines for Herbal Medicines (Phytotherapeutic Agents). Brazilian Journal of Medical and Biological Research, 33(2), 179–189. https://doi.org/10.1590/S0100-879X2000000200004
Campbell, L., Emmerson, E., Davies, F., Gilliver, S. C., Krust, A., Chambon, P., Ashcroft, G. S., & Hardman, M. J. (2010). Estrogen Promotes Cutaneous Wound Healing via Estrogen Receptor ? Independent of its Antiinflammatory Activities. Journal of Experimental Medicine, 207(9), 1825–1833. https://doi.org/10.1084/jem.20100500
Chatterjee, O., Patil, K., Sahu, A., Gopalakrishnan, L., Mol, P., Advani, J., Mukherjee, S., Christopher, R., & Prasad, T. S. K. (2016). An Overview of The Oxytocin-Oxytocin Receptor Signaling Network. Journal of Cell Communication and Signaling, 10(4), 355–360. https://doi.org/10.1007/s12079-016-0353-7
Demetrovici, L. (2020). Natural Sources of Nanoparticles. 1, 1–8. https://doi.org/10.1002/joc.v22
El Sayed, R. A. A., Hanafy, Z. E. M., El Fattah, H. F. A., & Amer, A. K. M. (2020). Possible Antioxidant and Anticancer Effects of Plants Extracts from Anastatica Hierochuntica, Lepidium Sativum and Carica Papaya against Ehrlich Ascites Carcinoma Cells. Cancer Biology Journal, 2507(1), 1–9. https://doi.org/10.7537/marscbj100120.01.Key
Faten, A. E., Eman, A. H., & Yahaya, G. (2016). Determination of Antioxidant and Anti-Inflammatory Activities, as Well as In Vitro Cytotoxic Activities of Extracts of Anastatica Hierochuntica (Kaff Maryam) Against HeLa Cell Lines. Journal of Medicinal Plants Research, 10(7), 77–87. https://doi.org/10.5897/jmpr2015.6030
Gechev, T. S., Hille, J., Woerdenbag, H. J., Benina, M., Mehterov, N., Toneva, V., Fernie, A. R., & Mueller-Roeber, B. (2014). Natural Products from Resurrection Plants: Potential for Medical Applications. Biotechnology Advances Journal, 32(6), 1091–1101. https://doi.org/10.1016/j.biotechadv.2014.03.005
Guyton, & Hall. (2006). Textbook od Medical Physiology. In Elseiver Saunders (Eleventh E).
Hegazy, A. K., & Kabiel, H. F. (2007). Significance of Microhabitat Heterogeneity in The Spatial Pattern and Size-Class Structure of Anastatica Hierochuntica L. Acta Oecologica Journal, 31(3), 332–342. https://doi.org/10.1016/j.actao.2007.01.006
Iravani, M., Janghorbani, M., Zarean, E., & Bahrami, M. (2015). An Overview of Systematic Reviews of Normal Labor and Delivery Management. Iranian Journal of Nursing and Midwifery Research, 20(3), 293–303.
Jigna, P., Rathish, N., & Sumitra, C. (2005). Preliminary Screening of Some Folklore Medicinal Plants From Western India for Potential Antimicrobial Activity. Indian Journal of Pharmacology, 37(6), 408–409. https://doi.org/10.4103/0253-7613.19085
Kamboj, V. . (2000). Herbal Medicine. Current Science Journal, 78(1), 35–39. https://doi.org/10.2165/00128415-200812320-00058
Kassebaum, N. J., Barber, R. M., Dandona, L., Hay, S. I., Larson, H. J., Lim, S. S., Lopez, A. D., Mokdad, A. H., Naghavi, M., Pinho, C., Steiner, C., Vos, T., Wang, H., Achoki, T., Anderson, G. M., Arora, M., Biryukov, S., Blore, J. D., Carter, A., … Zuhlke, L. J. (2016). Global, Regional, and National Levels of Maternal Mortality, 1990–2015: a Systematic Analysis for The Global Burden of Disease Study 2015. The Lancet, 388(10053), 1775–1812. https://doi.org/10.1016/S0140-6736(16)31470-2
Kim Sooi, L., & Lean Keng, S. (2013). Herbal Medicines: Malaysian Women’s Knowledge and Practice. Evidence-Based Complementary and Alternative Medicine, 2013. https://doi.org/10.1155/2013/438139
Kodan, L. R., Verschueren, K. J. C., van Roosmalen, J., Kanhai, H. H. H., & Bloemenkamp, K. W. M. (2017). Maternal Mortality Audit in Suriname Between 2010 and 2014, a Reproductive Age Mortality Survey. BMC Pregnancy and Childbirth, 17(1), 1–9. https://doi.org/10.1186/s12884-017-1466-6
Kodan, Verschueren, Roosmalen, V., Kanhai, & Bloemenkamp. (2017). Maternal Mortality Audit in Suriname Between 2010 and 2014, a Reproductive Age Mortality Survey. BMC Pregnancy and Childbirth, 17(1), 1–9. https://doi.org/10.1186/s12884-017-1466-6
Kyu, H. H., Abate, D., Abate, K. H., Abay, S. M., Abbafati, C., Abbasi, N., Abbastabar, H., Abd-Allah, F., Abdela, J., Abdelalim, A., Abdollahpour, I., Abdulkader, R. S., Abebe, M., Abebe, Z., Abil, O. Z., Aboyans, V., Abrham, A. R., Abu-Raddad, L. J., Abu-Rmeileh, N. M. E., … Murray, C. J. L. (2018). Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet, 392(10159), 1859–1922. https://doi.org/10.1016/S0140-6736(18)32335-3
Lecomte, S., Demay, F., Ferrière, F., & Pakdel, F. (2017). Phytochemicals Targeting Estrogen Receptors: Beneficial Rather Than Adverse Effects? International Journal of Molecular Sciences, 18(7), 1–19. https://doi.org/10.3390/ijms18071381
Mohankumar, J. B., Gladious, A. J., & Velvizhi, M. (2017). Antioxidant Content of Selected Medicinal Plants Used by Kaani Tribes of Kanyakumari District in Tamilnadu India. Journal of Food and Nutrition Research, 5(3), 180–186. https://doi.org/10.12691/jfnr-5-3-7
NICE. (2017). Intrapartum Care, Care of Healthy Women and Their Babies During Childbirth?: Clinical Guideline.
Norulaini, N. A. N., Anuar, O., Abbas, F. M. ., Omar, A. K. M., Sahena, F., & Zaidul, I. S. . (2009). Optimization of Supercritical CO 2 Extraction of Anastatica Hierochuntica. Food and Bioproducts Processing, 87(2), 152–158. https://doi.org/10.1017/j.fbp.2008.09.001
Organization., W. H. (2019). WHO Guideline: Recommendations on digital interventions for health system strengthening. In Food and Nutrition Bulletin. https://doi.org/10.1177/156482658000200103
Rameshbabu, S., Messaoudi, S. A., Alehaideb, Z. I., Ali, M. S., Venktraman, A., Alajmi, H., Al-Eidi, H., & Matou-Nasri, S. (2020). Anastatica hierochuntica (L.) Methanolic and Aqueous Extracts Exert Antiproliferative Effects Through the Induction of Apoptosis in MCF-7 Breast Cancer Cells. Saudi Pharmaceutical Journal, 28(8), 985–993. https://doi.org/10.1016/j.jsps.2020.06.020
Ross, H. E., Cole, C. D., Smith, Y., Neumann, I. D., Landgraf, R., Murphy, A. Z., & Young, L. J. (2009). Characterization of the oxytocin system regulating affiliative behavior in female prairie voles. Neuroscience, 162(4), 892–903. https://doi.org/10.1016/j.neuroscience.2009.05.055
Saleh, J., & Machado, L. (2012). Rose of Jericho: A Word of Caution. Oman Medical Journal, 27(4), 338. https://doi.org/10.5001/omj.2012.86
Sarli, D. (2017). Hubungan Kadar Hormon Oksitosin Terhadap Lama Kala Iii Persalinan Serta Pengaruhnya Terhadap Jumlah Perdarahan Pada Ibu 2 Jam Postpartum. Jik- Jurnal Ilmu Kesehatan, 1(1), 6–12. https://doi.org/10.33757/jik.v1i1.20
Sawada, K., Ikebuchi, Y., Kawagishi, R., Tasaka, K., & Murata, Y. (2002). RhoA / Rho-Kinase Cascade Is Involved in Oxytocin-. 143(3), 920–929.
Say, Chou, Gemmill, Tunçalp, Moller, Daniels, Gülmezoglu, Temmerman, & Alkema. (2014). Global Causes of Maternal Death: A WHO Systematic Analysis. The Lancet Global Health, 2(6), 323–333. https://doi.org/10.1016/S2214-109X(14)70227-X
Shaban, F., Al-azzawie, H. F., & Mohammed, A. S. (2011). Effect of Alcoholic Anastatica Hierochuntica Extract on Some Biochemical and Histological Parameters in Alloxan Induced Diabetic Rats. Iraqi Journal of Science, 52(4), 445–455.
Situmorang, Ilyas, Hutahaean, & Rosidah. (2019). Effect of Nanoherbal Andaliman (Zanthoxylum Acanthopodium) and Extra Virgin Olive Oil Combination on Preeclamptic Rats Liver Histology. Open Access Macedonian Journal of Medical Sciences, 7(14), 2226–2231.
Standring, S. (2016). Female Reproductive System. In Gray’s Anatomy: The Anatomical Basis of Clinical Female Practice?: Reproductive System: Vol. Forty Seco (pp. 249–249). Elsevier B.V. https://doi.org/10.5005/jp/books/12791_18
Stanton, C. K., Newton, S., Mullany, L. C., Cofie, P., Tawiah Agyemang, C., Adiibokah, E., Amenga-Etego, S., Darcy, N., Khan, S., Armbruster, D., Gyapong, J., & Owusu-Agyei, S. (2013). Effect on Postpartum Hemorrhage of Prophylactic Oxytocin (10 IU) by Injection by Community Health Officers in Ghana: A Community-Based, Cluster-Randomized Trial. PLoS Medicine, 10(10), 1–10. https://doi.org/10.1371/journal.pmed.1001524
Suckow, Franklin, & Weisborth. (2016). Laboratory Rat. https://doi.org/10.1016/B978-0-12-074903-4.50001-7
Surwade, V. (2020). Indian Journal of Public Health Research & Development. Indian Journal of Public Health Research & Develpoment, 11(2), 1–8. https://doi.org/ISSSN 0976-0245 (Print), 0976-5506 (Electronic)
Tariq, Z., Al-Dhanki, M., Farhan, A., Al-Enzy, M., Abdullah, A., & Al-Hamdani, Y. (2018). Effect of Aqueous Extract of Melia Azedarach L., Anastatica Hierochuntic and Enrofloxacin Antibiotic on Live Broiler Performance. Technology, Engineering & Mathematics (EPSTEM), 3(January).
Thornton, J. M., Browne, B., & Ramphul, M. (2020). Mechanisms and management of normal labour. Obstetrics, Gynaecology and Reproductive Medicine, 30(3), 84–90. https://doi.org/10.1016/j.ogrm.2019.12.002
Vakilian, K., Keramat, A., & Gharacheh, M. (2018). Controlled Breathing With or Without Lavender Aromatherapy for Labor Pain at the First Stage: A Randomized Clinical Trial. Crescent Journal of Medical and Biological Sciences, 5(3), 172–175.
WHO. (2014). WHO | South-East Asian Region. World Health Organization.
Yang, H.-P., Wang, L., Han, L., & Wang, S. C. (2013). Nonsocial Functions of Hypothalamic Oxytocin. ISRN Neuroscience, 2013, 1–13. https://doi.org/10.1155/2013/179272
Yoshikawa, M., Xu, F., Morikawa, T., Ninomiya, K., & Matsuda, H. (2003). Anastatins A and B, New Skeletal Flavonoids with Hepatoprotective Activities From the Desert Plant Anastatica Hierochuntica. Bioorganic and Medicinal Chemistry Letters, 13(6), 1045–1049. https://doi.org/10.1016/S0960-894X(03)00088-X
Zin, Siti Rosmani.Md, Mohamed, Z., Alshawsh, M. A., Wong, W. F., & Kassim, N. M. (2018). Mutagenicity Evaluation of Anastatica Hierochuntica L. Aqueous Extract In Vitro and In Vivo. Experimental Biology and Medicine, 243(4), 375–385. https://doi.org/10.1177/1535370217748574
Zin, Siti Rosmani MD, Kassim, N. M., Alshawsh, M. A., Hashim, N. E., & Mohamed, Z. (2017). Biological Activities of Anastatica Hierochuntica L .: A Systematic Review. Biomedicine et Pharmacotherapy, 91(2017), 611–620. https://doi.org/10.1016/j.biopha.2017.05.011
Abate, A., & Amanuel, A. (2012). Joint Review Mission: Final Report.
Abdulfattah, S. Y. (2013). Study of Immunological Effect of Anastatica Hierochuntica (Kaff Maryam) Plant Methanolic Extract on Albino Male Mice. Journal of Biotechnology Research Center, 7(1), 3–10.
Acevedo-Rodriguez, A., Mani, S. K., & Handa, R. J. (2015). Oxytocin and estrogen receptor ? in the brain: An overview. In Frontiers in Endocrinology (Vol. 6, Issue OCT). https://doi.org/10.3389/fendo.2015.00160
Aguilar, H. N., & Mitchell, B. F. (2010). Physiological Pathways And Molecular Mechanisms Regulating Uterine Contractility. Human Reproduction Update, 16(6), 725–744. https://doi.org/10.1093/humupd/dmq016
Al-Khafaji, A. N. (2018). Therapeutically and Synergism Effect Between Anastatica Hierochuntica and Antibiotics Against Multidrug Resistance Bacteria Isolate from Endometritis. Biochemical and Cellular Archives Journal, 18(2), 2143–2150.
Al-sultany, A. kariem, Al-Rahimy, S. K., Shaheed, K. abdulAlee, & Khalaf, M. A. (2019). Study of The Effect of Anastatica Hierochuntica L. Extracts in Aspects of The Life Performance of Tribolium Castaneum with The Diagnosis of Active compounds using GC-MAS. Biomedical Research, 30(1), 1–8. https://doi.org/10.35841/biomedicalresearch.30-18-1181
Alatshan, A., Qnais, E., Wedyan, M., Bseiso, Y., Alzyoud, E., Banat, R., & Alkhateeb, H. (2018). Antinociceptive and Antiinflammatory Activities of Anastatica hierochuntica and Possible Mechanism of Action. Indian Journal of Sciences, 80(May), 637–646.
Algamdi, N., Mullen, W., & Crozier, A. (2011a). Tea prepared from Anastatica hirerochuntica seeds contains a diversity of antioxidant flavonoids, chlorogenic acids and phenolic compounds. Phytochemistry, 72(2–3), 248–254. https://doi.org/10.1016/j.phytochem.2010.11.017
Algamdi, N., Mullen, W., & Crozier, A. (2011b). Tea Prepared from Anastatica Hirerochuntica Seeds Contains a Diversity of Antioxidant Flavonoids, Chlorogenic Acids and Phenolic Compounds. Phytochemistry Journal, 72(2–3), 248–254. https://doi.org/10.1016/j.phytochem.2010.11.017
Ali, B. H., Baker, R. K., Mohammd, T. U., & Hassn, H. A. (2013). Anastatica Hierochuntica L. Used As an Alternative of Conjugated Estrogen (Premarin) in Rabbit Females. Journal of Advances in Chemistry, 9(1), 1783–1786. https://doi.org/10.24297/jac.v9i1.2302
Astutik, H., Santoso, B., & Agil, M. (2020). The Effect of Anastatica Hierochuntica L. Extract on the Histology of Myometrial Cells and Prostaglandin Levels (PGE2, PGF2?) in Pregnant Mice. 22(Ishr 2019), 81–86. https://doi.org/10.2991/ahsr.k.200215.016
Baldisserotto, Filha, T., & Gama, D. (2016). Good Practices According to WHO’s Recommendation for Normal Labor and Birth and Women’s Assessment of the Care Received: The “Birth in Brazil” National Research study, 2011/2012. Reproductive Health, 13(3). https://doi.org/10.1186/s12978-016-0233-x
Benyagoub, E., Razni, D., & Moghtet, S. (2017). Phytochemical Composition of Anastatica Hierochuntica L., Can It Fight The Toxigenic Bacterial Agents Responsible for Food Poisoning? Microbes and Health Journal, 6(1), 5–8. https://doi.org/10.3329/mh.v6i1.34063
Çalik, K. Y., Karabulutlu, Ö., & Yavuz, C. (2018). First do no harm - Interventions during labor and maternal satisfaction: A descriptive cross-sectional study. BMC Pregnancy and Childbirth, 18(1), 1–10. https://doi.org/10.1186/s12884-018-2054-0
Calixto, J. B. (2000). Efficacy, Safety, Quality Control, Marketing and Regulatory Guidelines for Herbal Medicines (Phytotherapeutic Agents). Brazilian Journal of Medical and Biological Research, 33(2), 179–189. https://doi.org/10.1590/S0100-879X2000000200004
Campbell, L., Emmerson, E., Davies, F., Gilliver, S. C., Krust, A., Chambon, P., Ashcroft, G. S., & Hardman, M. J. (2010). Estrogen Promotes Cutaneous Wound Healing via Estrogen Receptor ? Independent of its Antiinflammatory Activities. Journal of Experimental Medicine, 207(9), 1825–1833. https://doi.org/10.1084/jem.20100500
Chatterjee, O., Patil, K., Sahu, A., Gopalakrishnan, L., Mol, P., Advani, J., Mukherjee, S., Christopher, R., & Prasad, T. S. K. (2016). An Overview of The Oxytocin-Oxytocin Receptor Signaling Network. Journal of Cell Communication and Signaling, 10(4), 355–360. https://doi.org/10.1007/s12079-016-0353-7
Demetrovici, L. (2020). Natural Sources of Nanoparticles. 1, 1–8. https://doi.org/10.1002/joc.v22
El Sayed, R. A. A., Hanafy, Z. E. M., El Fattah, H. F. A., & Amer, A. K. M. (2020). Possible Antioxidant and Anticancer Effects of Plants Extracts from Anastatica Hierochuntica, Lepidium Sativum and Carica Papaya against Ehrlich Ascites Carcinoma Cells. Cancer Biology Journal, 2507(1), 1–9. https://doi.org/10.7537/marscbj100120.01.Key
Faten, A. E., Eman, A. H., & Yahaya, G. (2016). Determination of Antioxidant and Anti-Inflammatory Activities, as Well as In Vitro Cytotoxic Activities of Extracts of Anastatica Hierochuntica (Kaff Maryam) Against HeLa Cell Lines. Journal of Medicinal Plants Research, 10(7), 77–87. https://doi.org/10.5897/jmpr2015.6030
Gechev, T. S., Hille, J., Woerdenbag, H. J., Benina, M., Mehterov, N., Toneva, V., Fernie, A. R., & Mueller-Roeber, B. (2014). Natural Products from Resurrection Plants: Potential for Medical Applications. Biotechnology Advances Journal, 32(6), 1091–1101. https://doi.org/10.1016/j.biotechadv.2014.03.005
Guyton, & Hall. (2006). Textbook od Medical Physiology. In Elseiver Saunders (Eleventh E).
Hegazy, A. K., & Kabiel, H. F. (2007). Significance of Microhabitat Heterogeneity in The Spatial Pattern and Size-Class Structure of Anastatica Hierochuntica L. Acta Oecologica Journal, 31(3), 332–342. https://doi.org/10.1016/j.actao.2007.01.006
Iravani, M., Janghorbani, M., Zarean, E., & Bahrami, M. (2015). An Overview of Systematic Reviews of Normal Labor and Delivery Management. Iranian Journal of Nursing and Midwifery Research, 20(3), 293–303.
Jigna, P., Rathish, N., & Sumitra, C. (2005). Preliminary Screening of Some Folklore Medicinal Plants From Western India for Potential Antimicrobial Activity. Indian Journal of Pharmacology, 37(6), 408–409. https://doi.org/10.4103/0253-7613.19085
Kamboj, V. . (2000). Herbal Medicine. Current Science Journal, 78(1), 35–39. https://doi.org/10.2165/00128415-200812320-00058
Kassebaum, N. J., Barber, R. M., Dandona, L., Hay, S. I., Larson, H. J., Lim, S. S., Lopez, A. D., Mokdad, A. H., Naghavi, M., Pinho, C., Steiner, C., Vos, T., Wang, H., Achoki, T., Anderson, G. M., Arora, M., Biryukov, S., Blore, J. D., Carter, A., … Zuhlke, L. J. (2016). Global, Regional, and National Levels of Maternal Mortality, 1990–2015: a Systematic Analysis for The Global Burden of Disease Study 2015. The Lancet, 388(10053), 1775–1812. https://doi.org/10.1016/S0140-6736(16)31470-2
Kim Sooi, L., & Lean Keng, S. (2013). Herbal Medicines: Malaysian Women’s Knowledge and Practice. Evidence-Based Complementary and Alternative Medicine, 2013. https://doi.org/10.1155/2013/438139
Kodan, L. R., Verschueren, K. J. C., van Roosmalen, J., Kanhai, H. H. H., & Bloemenkamp, K. W. M. (2017). Maternal Mortality Audit in Suriname Between 2010 and 2014, a Reproductive Age Mortality Survey. BMC Pregnancy and Childbirth, 17(1), 1–9. https://doi.org/10.1186/s12884-017-1466-6
Kodan, Verschueren, Roosmalen, V., Kanhai, & Bloemenkamp. (2017). Maternal Mortality Audit in Suriname Between 2010 and 2014, a Reproductive Age Mortality Survey. BMC Pregnancy and Childbirth, 17(1), 1–9. https://doi.org/10.1186/s12884-017-1466-6
Kyu, H. H., Abate, D., Abate, K. H., Abay, S. M., Abbafati, C., Abbasi, N., Abbastabar, H., Abd-Allah, F., Abdela, J., Abdelalim, A., Abdollahpour, I., Abdulkader, R. S., Abebe, M., Abebe, Z., Abil, O. Z., Aboyans, V., Abrham, A. R., Abu-Raddad, L. J., Abu-Rmeileh, N. M. E., … Murray, C. J. L. (2018). Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet, 392(10159), 1859–1922. https://doi.org/10.1016/S0140-6736(18)32335-3
Lecomte, S., Demay, F., Ferrière, F., & Pakdel, F. (2017). Phytochemicals Targeting Estrogen Receptors: Beneficial Rather Than Adverse Effects? International Journal of Molecular Sciences, 18(7), 1–19. https://doi.org/10.3390/ijms18071381
Mohankumar, J. B., Gladious, A. J., & Velvizhi, M. (2017). Antioxidant Content of Selected Medicinal Plants Used by Kaani Tribes of Kanyakumari District in Tamilnadu India. Journal of Food and Nutrition Research, 5(3), 180–186. https://doi.org/10.12691/jfnr-5-3-7
NICE. (2017). Intrapartum Care, Care of Healthy Women and Their Babies During Childbirth?: Clinical Guideline.
Norulaini, N. A. N., Anuar, O., Abbas, F. M. ., Omar, A. K. M., Sahena, F., & Zaidul, I. S. . (2009). Optimization of Supercritical CO 2 Extraction of Anastatica Hierochuntica. Food and Bioproducts Processing, 87(2), 152–158. https://doi.org/10.1017/j.fbp.2008.09.001
Organization., W. H. (2019). WHO Guideline: Recommendations on digital interventions for health system strengthening. In Food and Nutrition Bulletin. https://doi.org/10.1177/156482658000200103
Rameshbabu, S., Messaoudi, S. A., Alehaideb, Z. I., Ali, M. S., Venktraman, A., Alajmi, H., Al-Eidi, H., & Matou-Nasri, S. (2020). Anastatica hierochuntica (L.) Methanolic and Aqueous Extracts Exert Antiproliferative Effects Through the Induction of Apoptosis in MCF-7 Breast Cancer Cells. Saudi Pharmaceutical Journal, 28(8), 985–993. https://doi.org/10.1016/j.jsps.2020.06.020
Ross, H. E., Cole, C. D., Smith, Y., Neumann, I. D., Landgraf, R., Murphy, A. Z., & Young, L. J. (2009). Characterization of the oxytocin system regulating affiliative behavior in female prairie voles. Neuroscience, 162(4), 892–903. https://doi.org/10.1016/j.neuroscience.2009.05.055
Saleh, J., & Machado, L. (2012). Rose of Jericho: A Word of Caution. Oman Medical Journal, 27(4), 338. https://doi.org/10.5001/omj.2012.86
Sarli, D. (2017). Hubungan Kadar Hormon Oksitosin Terhadap Lama Kala Iii Persalinan Serta Pengaruhnya Terhadap Jumlah Perdarahan Pada Ibu 2 Jam Postpartum. Jik- Jurnal Ilmu Kesehatan, 1(1), 6–12. https://doi.org/10.33757/jik.v1i1.20
Sawada, K., Ikebuchi, Y., Kawagishi, R., Tasaka, K., & Murata, Y. (2002). RhoA / Rho-Kinase Cascade Is Involved in Oxytocin-. 143(3), 920–929.
Say, Chou, Gemmill, Tunçalp, Moller, Daniels, Gülmezoglu, Temmerman, & Alkema. (2014). Global Causes of Maternal Death: A WHO Systematic Analysis. The Lancet Global Health, 2(6), 323–333. https://doi.org/10.1016/S2214-109X(14)70227-X
Shaban, F., Al-azzawie, H. F., & Mohammed, A. S. (2011). Effect of Alcoholic Anastatica Hierochuntica Extract on Some Biochemical and Histological Parameters in Alloxan Induced Diabetic Rats. Iraqi Journal of Science, 52(4), 445–455.
Situmorang, Ilyas, Hutahaean, & Rosidah. (2019). Effect of Nanoherbal Andaliman (Zanthoxylum Acanthopodium) and Extra Virgin Olive Oil Combination on Preeclamptic Rats Liver Histology. Open Access Macedonian Journal of Medical Sciences, 7(14), 2226–2231.
Standring, S. (2016). Female Reproductive System. In Gray’s Anatomy: The Anatomical Basis of Clinical Female Practice?: Reproductive System: Vol. Forty Seco (pp. 249–249). Elsevier B.V. https://doi.org/10.5005/jp/books/12791_18
Stanton, C. K., Newton, S., Mullany, L. C., Cofie, P., Tawiah Agyemang, C., Adiibokah, E., Amenga-Etego, S., Darcy, N., Khan, S., Armbruster, D., Gyapong, J., & Owusu-Agyei, S. (2013). Effect on Postpartum Hemorrhage of Prophylactic Oxytocin (10 IU) by Injection by Community Health Officers in Ghana: A Community-Based, Cluster-Randomized Trial. PLoS Medicine, 10(10), 1–10. https://doi.org/10.1371/journal.pmed.1001524
Suckow, Franklin, & Weisborth. (2016). Laboratory Rat. https://doi.org/10.1016/B978-0-12-074903-4.50001-7
Surwade, V. (2020). Indian Journal of Public Health Research & Development. Indian Journal of Public Health Research & Develpoment, 11(2), 1–8. https://doi.org/ISSSN 0976-0245 (Print), 0976-5506 (Electronic)
Tariq, Z., Al-Dhanki, M., Farhan, A., Al-Enzy, M., Abdullah, A., & Al-Hamdani, Y. (2018). Effect of Aqueous Extract of Melia Azedarach L., Anastatica Hierochuntic and Enrofloxacin Antibiotic on Live Broiler Performance. Technology, Engineering & Mathematics (EPSTEM), 3(January).
Thornton, J. M., Browne, B., & Ramphul, M. (2020). Mechanisms and management of normal labour. Obstetrics, Gynaecology and Reproductive Medicine, 30(3), 84–90. https://doi.org/10.1016/j.ogrm.2019.12.002
Vakilian, K., Keramat, A., & Gharacheh, M. (2018). Controlled Breathing With or Without Lavender Aromatherapy for Labor Pain at the First Stage: A Randomized Clinical Trial. Crescent Journal of Medical and Biological Sciences, 5(3), 172–175.
WHO. (2014). WHO | South-East Asian Region. World Health Organization.
Yang, H.-P., Wang, L., Han, L., & Wang, S. C. (2013). Nonsocial Functions of Hypothalamic Oxytocin. ISRN Neuroscience, 2013, 1–13. https://doi.org/10.1155/2013/179272
Yoshikawa, M., Xu, F., Morikawa, T., Ninomiya, K., & Matsuda, H. (2003). Anastatins A and B, New Skeletal Flavonoids with Hepatoprotective Activities From the Desert Plant Anastatica Hierochuntica. Bioorganic and Medicinal Chemistry Letters, 13(6), 1045–1049. https://doi.org/10.1016/S0960-894X(03)00088-X
Zin, Siti Rosmani.Md, Mohamed, Z., Alshawsh, M. A., Wong, W. F., & Kassim, N. M. (2018). Mutagenicity Evaluation of Anastatica Hierochuntica L. Aqueous Extract In Vitro and In Vivo. Experimental Biology and Medicine, 243(4), 375–385. https://doi.org/10.1177/1535370217748574
Zin, Siti Rosmani MD, Kassim, N. M., Alshawsh, M. A., Hashim, N. E., & Mohamed, Z. (2017). Biological Activities of Anastatica Hierochuntica L .: A Systematic Review. Biomedicine et Pharmacotherapy, 91(2017), 611–620. https://doi.org/10.1016/j.biopha.2017.05.011