The Mental Health in Women with Polycystic Ovary Syndrome (PCOS): A Scoping Review

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Dini Asrika Devi
Farida Kartini


Background: Women of childbearing age with Polycystic Ovary Syndrome (PCOS) are very susceptible to menstrual disorders, stress, and infertility. Psychological comorbidities are also common in women with PCOS, which impair overall quality of life. Although there has been a review of PCOS, it is not related to mental health. Therefore, it is necessary to review articles on mental health for women with PCOS.

Purpose: To determine the mental health of women with Polycystic Ovary Syndrome

Methods: This literature review applied a scoping review approach adapted to the PRISMA-ScR checklist framework. Three databases were used in the review, namely Pubmed, ESHRE, and SciencDirect. Prisma Flowchart was used for article seletion and the critical appraisal referred to Joanna Briggs Institute (JBI) critical appraisal tool.

Results: The database search resulted in 253 relevant topics and generated 10 most relevant articles to the research objectives as the final results. These researches were conducted in various countries using various approaches ranging from qualitative research, cross-sectional study, case control, cohort, and RCT. Three themes were obtained from the data base mapping, namely determinants, effectiveness, and mental health impacts on PCOS women

Conclusion: Women with PCOS mostly suffered from psychological disorders, especially at the level of anxiety. There is a correlation between mental health and PCOS, which results in decreased quality of life due to stress/depression, increased anxiety, and poor sleep quality. In this case, Pioglitazone Metformin (PM) is not a sufficient treatment for the symptoms, and thus additional therapy such as cognitive-behavioral therapy (CBT) is needed as assistance.

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How to Cite
Devi, D. A., & Kartini, F. (2022). The Mental Health in Women with Polycystic Ovary Syndrome (PCOS): A Scoping Review. Women, Midwives and Midwifery, 2(3), 1-19. Retrieved from


Abdollahi, L., Mirghafourvand, M., Babapour, J. K., & Mozhdeh, M. (2019). Effectiveness of cognitive-behavioral therapy (CBT) in improving the quality of life and psychological fatigue in women with polycystic ovarian syndrome: a randomized controlled clinical trial. Journal of Psychosomatic Obstetrics and Gynaecology, 40(4), 283–293.

Açmaz, G., Albayrak, E., Acmaz, B., Ba?er, M., Soyak, M., Zararsiz, G., & Ipekmüderris, I. (2013). Level of anxiety, depression, self-esteem, social anxiety, and quality of life among the women with polycystic ovary syndrome. The Scientific World Journal, 2013.

Agista, N. T. (2019). Psikologi Perempuan dengan Masalah Infertilitas Studi Fenomenologi pada Wanita di Halim Fertility Center Tahun 2017. 38.

Ahmadi, M., Faramarzi, M., Basirat, Z., Kheirkhah, F., Chehrazi, M., & Ashabi, F. (2020). Mental and personality disorders in infertile women with polycystic ovary: A case-control study. In African Health Sciences.

Alkoudsi, K. T., & Basheti, I. A. (2020). Prevalence of anxiety and depression among women with Polycystic Ovary Syndrome living in war versus non-war zone countries: A randomized controlled trial assessing a pharmacist intervention. Research in Social and Administrative Pharmacy, 16(5), 689–698.

Asdaq, S. M. B., Jomah, S., Hasan, R., Al-Baroudi, D., Alharbi, M., Alsubaie, S., Buhamad, M. H., Alyahya, B., & Al-Yamani, M. J. (2020). Impact of polycystic ovary syndrome on eating behavior, depression and health related quality of life: A cross-sectional study in Riyadh. Saudi Journal of Biological Sciences, 27(12), 3342–3347.

Asdaq, S. M. B., & Yasmin, F. (2020). Risk of psychological burden in polycystic ovary syndrome: A case control study in Riyadh, Saudi Arabia. Journal of Affective Disorders, 274, 205–209.

Borghi, L., Leone, D., Vegni, E., Galiano, V., Lepadatu, C., Sulpizio, P., & Garzia, E. (2018). Psychological distress, anger and quality of life in polycystic ovary syndrome: associations with biochemical, phenotypical andsocio-demographic factors. Journal of Psychosomatic Obstetrics and Gynecology, 39(2), 128–137.

Ekramzadeh, M., Hajivandi, L., Noroozi, M., & Mostafavi, F. (2020). Psychological experiences of adolescent girls with polycystic ovary syndrome: A qualitative study. Iranian Journal of Nursing and Midwifery Research, 25(4), 341–347.

Evertsz, F. B., Sprangers, M. A. G., Kate, S., Stokkers, P. C. F., Ponsioen, C. Y., Bartelsman, J. F. W. M., Bodegraven, A. A. van, Fischer, S., Depla, A. C. T. M., Mallant, R. C., Sanderma, R., & Bockting, C. L. H. (2017). Effectiveness of cognitive-behavioral therapy on quality of life, anxiety, and depressive symptoms among patients with inflammatory bowel disease: A multicenter randomized controlled trial. J Consult Clin Psychol.

Fauser, B. C. J. M., Tarlatzis, B. C., Rebar, R. W., Legro, R. S., Balen, A. H., Lobo, R., Carmina, E., Chang, J., Yildiz, B. O., Laven, J. S. E., Boivin, J., Petraglia, F., Wijeyeratne, C. N., Norman, R. J., Dunaif, A., Franks, S., Wild, R. A., Dumesic, D., & Barnhart, K. (2012). Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): The Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group. Fertility and Sterility, 97(1), 28-38.e25.

Greenwood, E. A., Pasch, L. A., Cedars, M. I., Legro, R. S., & Huddleston, H. G. (2018). Association among depression, symptom experience, and quality of life in polycystic ovary syndrome. American Journal of Obstetrics and Gynecology, 219(3), 279.e1-279.e7.

Guo, Q., Shan, J., Xu, Y., Hu, Y., Huo, C., Song, J., Wang, C., Zhou, H., Yu, C., & Huang, Q. (2020). Pioglitazone Metformin Complex Improves Polycystic Ovary Syndrome Comorbid Psychological Distress via Inhibiting NLRP3 Inflammasome Activation: A Prospective Clinical Study. Mediators of Inflammation, 2020, 3050487.

Karsten, M. D. A., Wekker, V., Groen, H., Painter, R. C., Mol, B. W. J., Laan, E. T. M., Roseboom, T. J., & Hoek, A. (2021). The role of PCOS in mental health and sexual function in women with obesity and a history of infertility. Human Reproduction Open, 2021(4), 1–11.


Kite, C., Atkinson, L., McGregor, G., Clark, C. C. T., Brown, J. E., Kyrou, I., & Randeva, H. S. (2021). Sleep Disruption and Depression, Stress and Anxiety Levels in Women With Polycystic Ovary Syndrome (PCOS) During the Lockdown Measures for COVID-19 in the UK. Frontiers in Global Women’s Health, 2(June), 1–9.

LI, S., Dan-ni, Z., LI, W., & YANG, J. (2017). Mental health status assessment in polycystic ovarian syndrome infertility patients: A pilot study. Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban, 37(5), 750–754.

Munn, Z., Peters, M. D. J., Stern, C., Tufanaru, C., McArthur, A., & Aromataris, E. (2018). Systematic review or scoping review? Guidance for authors when choosing between a systematic or scoping review approach. BMC Medical Research Methodology, 18(1), 1–8.

Peterson, J., Pearce, P. F., Ferguson, L. A., & Langford, C. A. (2017). Understanding scoping reviews: Definition, purpose, and process. Journal of the American Association of Nurse Practitioners, 29(1), 12–16.

Pham, M. T., Raji?, A., Greig, J. D., Sargeant, J. M., Papadopoulos, A., & Mcewen, S. A. (2014). A scoping review of scoping reviews: Advancing the approach and enhancing the consistency. Research Synthesis Methods, 5(4), 371–385.

Pollock, D., Davies, E. L., Peters, M. D. J., Tricco, A. C., Alexander, L., McInerney, P., Godfrey, C. M., Khalil, H., & Munn, Z. (2021). Undertaking a scoping review: A practical guide for nursing and midwifery students, clinicians, researchers, and academics. Journal of Advanced Nursing, 77(4), 2102–2113.

Putri, A., Jatmiko, S. W., Lestari, N., & Nursanto, D. (2021). Disfungsi Seksual Pada Wanita Dengan Polikistik Ovarium Sindrom?: Systematic Review. 407–416.

Saputra, A. N. D. (2019). Polycystic Ovary Syndrome (PCOS) pada Remaja. Pediatrics, 136(6), 1154–1165.

Sayyah-Melli, M., Alizadeh, M., Pourafkary, N., Ouladsahebmadarek, E., Jafari-Shobeiri, M., Abbassi, J., Kazemi-Shishvan, M. alsadat, & Sedaghat, K. (2015). Psychosocial Factors Associated with Polycystic Ovary Syndrome: a Case Control Study. Journal of Caring Sciences, 4(3), 225–231.

Shabani, A., Foroozanfard, F., Kavossian, E., Aghadavod, E., Ostadmohammadi, V., Reiter, R. J., Eftekhar, T., & Asemi, Z. (2019). Effects of melatonin administration on mental health parameters, metabolic and genetic profiles in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial. Journal of Affective Disorders, 250, 51–56.

Tricco, A. C., Langlois, E. V, & Straus, S. E. (2017). Rapid Reviews to Strengthen Health Policy and Systems: A Practical Guide. In World Health Organisation (Issue September).

Tricco, C, A., Lillie, Erin, Zarin, & Al, W. et. (2018). PRISMA extension for scoping reviews (PRISMA-ScR): Checklist and explanation. July.

WHO. (2020). Hrp Annual Report 2020.

Yang, Y., Deng, H., Li, T., Xia, M., Liu, C., Bu, X.-Q., Li, H., Fu, L.-J., & Zhong, Z.-H. (2021). The mental health of Chinese women with polycystic ovary syndrome is related to sleep disorders, not disease status. Journal of Affective Disorders, 282, 51–57.

Zisapel, N. (2018). New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation. British Journal of Pharmacology, 175(16), 3190–3199.