Neonatal Jaundice Causal Factors: A Literature Review

Main Article Content

Pariqa Annisa
Andari Wuri Astuti
Surabhi Sharma


Background: Jaundice (neonatal icterus), known as yellowish baby is a condition where the yellowing of the skin and sclera in newborns, due to increased levels of bilirubin in the blood (hyperbilirubinemia) which subsequently causes an increase in bilirubin in the fluid outside the cell (extracellular fluid). Jaundice is one of the contributors to infant morbidity in Indonesia because it can cause the baby's body to become limp, unwilling to suck, increased muscle tone, stiff neck, muscle spasms, convulsions, sensory disturbances, mental retardation, disability, and even death.

Objective: This study aimed to review the evidence related to the factors causing jaundice in neonates.

Method: This research method was a literature review study. Journal searches were carried out by applying online database such as ScienceDirect and PubMed. Author also used google scholar for search engine. The inclusion criteria in this study were journals published in 2015-2020 using Indonesian and English and full text. Journal search results obtained as many as 10 journals were reviewed in this study.

Results: Birth weight of the baby, gestational age, asphyxia, infection, length of labor, frequency and sex are factors that cause jaundice while primiparous mothers are factors that do not cause jaundice. Based on the results of the review of the article the researchers found that there were gaps in the study this is research on the factors causing the occurrence of jaundice more focused on health problems of birth weight of the baby, gestational age, asphyxia, and infection, duration of delivery, frequency and sex. Only few researches are examining the factors associated with factors causing jaundice in neonates.

Conclusion: The factors causing the occurrence neonatal jaundice are more focused on health problems of birth weight of babies, gestational age, asphyxia, infection, length of labor, frequency and sex. There are still few studies that examine the factors associated with factors that cause jaundice in neonates.

Article Details

How to Cite
Annisa, P., Astuti, A. W. ., & Sharma, S. (2023). Neonatal Jaundice Causal Factors: A Literature Review. Women, Midwives and Midwifery, 3(1), 45-60.


Amandito, Putradista, Jikesya, Utaminingsih, Rusin, & Rohsiswatna. (2018). UGT1A1 Gene and Neonatal Hyperbilirubinemia: A Preliminary Study from Bengkulu, Indonesia. In BMC Research Notes (pp. 1–6).

Anwar, Green, Norris, & Bukhari. (2015). Self-medication, home remedies, and spiritual healing: common responses to everyday symptoms in Pakistan. Health Psychology and Behavioral Medicine, 3(1), 281–295.

Arksey, & O’Malley. (2015). Scoping studies: Towards a methodological framework. International Journal of Social Research Methodology: Theory and Practice, 8(1), 19–32. doi: 10.1080/1364557032000119616.

Battersby, Longford, Patel, Selby, Ojha, Dorling, & Gale. (2018). Study protocol: Optimising newborn nutrition during and after neonatal therapeutic hypothermia in the United Kingdom: observational study of routinely collected data using propensity matching. BMJ Open, 8(10), 26–39.

Cisco. (2014). Teaching the literature review: A practical approach for college instructors. Teaching and Learning Inquiry.

Damarini, S., Eliana, E., & Mariati, M. (2013). The Effectiveness of Red Betel in Healing Perineal Wound in Independent Practicioner Midwive. Kesmas: National Public Health Journal, 8(1), 39.

Dong, Chen, White, Wang, Hu, Liang, & Xia. (2018). Meconium microbiome associates with the development of neonatal jaundice. Clinical and Translational Gastroenterology, 9(9).

Fox, McMullen, & Newburn. (2015). UK women’s experiences of breastfeeding and additional breastfeeding support: A qualitative study of Baby Café services. BMC Pregnancy and Childbirth, 15(1), 147.

Govoni, L., Ricchi, A., Molinazzi, M. T., Galli, M. C., Putignano, A., Artioli, G., Foà, C., Palmieri, E., & Neri, I. (2019). Breastfeeding pathologies: Analysis of prevalence, risk and protective factors. Acta Biomedica, 90, 56–62.

Hashim, Ishak, & Muhammad. (2020). Unsuccessful Exclusive Breastfeeding and Associated Factors among the Healthcare Providers in East Coast, Malaysia. Korean Journal of Family Medicine, 41(6), 416–421.

Kutty. (2019). Breastfeeding during breast milk jaundice-a pathophysiological perspective. Medical Journal of Malaysia, 74(6), 527–533.

Kyu, H. H., Abate, D., Abate, K. H., Abay, S. M., Abbafati, C., Abbasi, N., Abbastabar, H., Abd-Allah, F., Abdela, J., Abdelalim, A., Abdollahpour, I., Abdulkader, R. S., Abebe, M., Abebe, Z., Abil, O. Z., Aboyans, V., Abrham, A. R., Abu-Raddad, L. J., Abu-Rmeileh, N. M. E., … Murray, C. J. L. (2018). Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet, 392(10159), 1859–1922.

Maryunani. (2013). Trans Info Media. Jakarta. West Nusa Tenggara in 2018. NTB: Department of Health. Accessed through the Indonesian Health Profile. Indonesian Health Profile 2015. Indonesia Health Profile. at 16.07 WIB.

Ministry of Health, L. and W. (2013). Guide for the prevention of child abuse.

Mubasyiroh, R., Putri, I., & Tjandrarini, D. (2017). Mental Emotional Symptoms’ Determinants of Junior-Senior High School Student in Indonesia 2015. 45(2), 103–112.

Nuraeni, Agustini, & Kurniawan. (2018). Factors Associated with the Incidence of Anemia in Pregnant Women in the Work Area of the Cigasong Health Center UPTD in 2017.

Olusanya, Osibanjo, & Slusher. (2015). Risk Factors for Severe Neonatal Hyperbilirubinemia in Low and Middle-Income Countries: A Systematic Review and Meta-Analysis. In Journal PLOS one.

Otsuka, Dennis, Tatsuoka, & Jimba. (2008). The relationship between breastfeeding self-efficacy and perceived insufficient milk among Japanese mothers. Journal of Obstetric, Gynecologic & Neonatal Nursing, 37(1), 546–555.

Puspita. (2018). The Effect of Low Birthweight on the Incidence of Neonatal Jaundice in Sidoarjo. Jurnal Berkala Epidemiologi, 6(2), 174.

Rahman, A. E., Perkins, J., Islam, S., Siddique, A. B., Moinuddin, M., Anwar, M. R., Mazumder, T., Ansar, A., Rahman, M. M., Raihana, S., Capello, C., Santarelli, C., El Arifeen, S., & Hoque, D. M. E. (2018). Knowledge and involvement of husbands in maternal and newborn health in rural Bangladesh. BMC Pregnancy and Childbirth, 18(1), 1–12.

Septianingrum, & Yasintha. (2018). Attachment Mother and Child Through Play. In 4th ASEAN Conference on Psychology, Counselling, and Humanities (ACPCH 2018).

Seyedi, Mirghafourvand, Dost, Mohammad-Alizadeh-Charandabi, & Jafarabadi. (2019). Relationship between neonatal skin bilirubin level and severe jaundice with maternal, childbirth, and neonatal characteristics. Iranian Journal of Neonatology, 10(2), 61–67.

Tani, F., & Castagna, V. (2017). Maternal social support, quality of birth experience, and post-partum depression in primiparous women. Journal of Maternal-Fetal and Neonatal Medicine, 30(6), 689–692.

Thielemans, Trip-Hoving, Landier, Turner, Prins, Wouda, & Carrara. (2018). Indirect neonatal hyperbilirubinemia in hospitalized neonates on the Thai-Myanmar border: A review of neonatal medical records from 2009 to 2014. BMC Pediatrics, 18(1), 1–11.

Yuliawati, & Astutik. (2018). The Relationship Between Perinatal and Neonatal Factors on The Neonatal Jaundice. Jurnal Ners Dan Kebidanan, 5(2), 83–89.